Unraveling neuroprotection with Kv1.3 potassium channel blockade by a scorpion venom peptide

Unraveling neuroprotection with Kv1.3 potassium channel blockade by a scorpion venom peptide

Abstract Voltage-gated potassium channels play a crucial role in cellular repolarization and are potential therapeutic targets in neuroinflammatory disorders and neurodegenerative diseases. This study explores Tityus bahiensis scorpion venom for neuroactive peptides. We identified the αKtx12 peptide...

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Bibliographic Details
Main Authors: Emidio Beraldo-Neto, Vanessa Florentino Ferreira, Hugo Vigerelli, Karolina Rosa Fernandes, Maria Aparecida Juliano, Ana Leonor Abrahao Nencioni, Daniel Carvalho Pimenta
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Voltage-gated potassium channel
Neurotoxin
Hippocampus
Scorpion toxin
Kv1.3
αKtx12
Online Access:https://doi.org/10.1038/s41598-024-79152-1
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https://doi.org/10.1038/s41598-024-79152-1

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