“Clickable” Nanoparticles for Targeted Imaging
Nanomaterials functionalized with targeting ligands are increasingly recognized as useful materials for molecular imaging and drug delivery. Here we describe the development and validation of azide–alkyne reactions (“click chemistry”) for the rapid, site-specific modification of nanoparticles with s...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2006-04-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2006.00013 |
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| _version_ | 1841561892260151296 |
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| author | Eric Yi Sun Lee Josephson Ralph Weissleder |
| author_facet | Eric Yi Sun Lee Josephson Ralph Weissleder |
| author_sort | Eric Yi Sun |
| collection | DOAJ |
| description | Nanomaterials functionalized with targeting ligands are increasingly recognized as useful materials for molecular imaging and drug delivery. Here we describe the development and validation of azide–alkyne reactions (“click chemistry”) for the rapid, site-specific modification of nanoparticles with small molecules. The facile preparation of stable nanoparticles bearing azido or alkyne groups capable of reaction with their corresponding counterpart functionalized small molecules is demonstrated. The Cu(I)-catalyzed cycloaddition of azides and alkynes is shown to be a highly efficient and selective method for point functionalization of magnetic nanoparticles. Derivatized nanoparticles bearing biotin, fluorochrome, or steroid moieties are stable for several months. Nanoparticle click chemistry will be useful for other nanomaterials, design of novel sensors, and drug delivery vehicles. |
| format | Article |
| id | doaj-art-e9ff0699bf7041d18f6edb6d32d779a9 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2006-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-e9ff0699bf7041d18f6edb6d32d779a92025-01-03T01:22:46ZengSAGE PublishingMolecular Imaging1536-01212006-04-01510.2310/7290.2006.0001310.2310_7290.2006.00013“Clickable” Nanoparticles for Targeted ImagingEric Yi SunLee JosephsonRalph WeisslederNanomaterials functionalized with targeting ligands are increasingly recognized as useful materials for molecular imaging and drug delivery. Here we describe the development and validation of azide–alkyne reactions (“click chemistry”) for the rapid, site-specific modification of nanoparticles with small molecules. The facile preparation of stable nanoparticles bearing azido or alkyne groups capable of reaction with their corresponding counterpart functionalized small molecules is demonstrated. The Cu(I)-catalyzed cycloaddition of azides and alkynes is shown to be a highly efficient and selective method for point functionalization of magnetic nanoparticles. Derivatized nanoparticles bearing biotin, fluorochrome, or steroid moieties are stable for several months. Nanoparticle click chemistry will be useful for other nanomaterials, design of novel sensors, and drug delivery vehicles.https://doi.org/10.2310/7290.2006.00013 |
| spellingShingle | Eric Yi Sun Lee Josephson Ralph Weissleder “Clickable” Nanoparticles for Targeted Imaging Molecular Imaging |
| title | “Clickable” Nanoparticles for Targeted Imaging |
| title_full | “Clickable” Nanoparticles for Targeted Imaging |
| title_fullStr | “Clickable” Nanoparticles for Targeted Imaging |
| title_full_unstemmed | “Clickable” Nanoparticles for Targeted Imaging |
| title_short | “Clickable” Nanoparticles for Targeted Imaging |
| title_sort | clickable nanoparticles for targeted imaging |
| url | https://doi.org/10.2310/7290.2006.00013 |
| work_keys_str_mv | AT ericyisun clickablenanoparticlesfortargetedimaging AT leejosephson clickablenanoparticlesfortargetedimaging AT ralphweissleder clickablenanoparticlesfortargetedimaging |