Decoding dengue’s neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model

Decoding dengue’s neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model

Abstract Background Dengue encephalitis, a severe neurological complication of dengue virus infection, is increasingly recognized for its rising incidence and significant public health burden. Despite its growing prevalence, the underlying mechanisms and effective therapeutic strategies remain poorl...

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Main Authors: Minyue Qiu, Lixin Zhao, Xiaojia Li, Yipei Fan, Minchi Liu, Dong Hua, Yunkai Zhu, Yinyin Liang, Yu Zhang, Wen Xiao, Xiaofeng Xu, Jintao Li
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Neuroinflammation
Subjects:
Dengue encephalitis
Single-nucleus RNA sequencing
GABAergic neurons
Immune cell infiltration
CD8+ T cells
Neurological impairment
Online Access:https://doi.org/10.1186/s12974-025-03383-w
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https://doi.org/10.1186/s12974-025-03383-w

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