Single nucleosome imaging reveals principles of transient multiscale chromatin reorganization triggered by histone ADP-ribosylation at DNA lesions

Single nucleosome imaging reveals principles of transient multiscale chromatin reorganization triggered by histone ADP-ribosylation at DNA lesions

Abstract Timely access to DNA lesions is crucial for genome integrity. This process requires profound remodeling of densely packed chromatin to establish a repair-competent architecture. However, limited resolution has made it impossible to fully understand these remodeling events. Here, combining m...

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Main Authors: Fabiola García Fernández, Junwoo Park, Catherine Chapuis, Eva Pinto Jurado, Victor Imburchia, Rebecca Smith, Edoardo José Longarini, Angela Taddei, Christian Hubert, Nataliya Sokolovska, Ivan Matić, Sébastien Huet, Judith Miné-Hattab
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61834-7
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https://doi.org/10.1038/s41467-025-61834-7

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