Sulfide, Sulfoxide, and Sulfone Derivatives of Usnic Acid as Inhibitors of Human TDP1 and TDP2 Enzymes

Sulfide, Sulfoxide, and Sulfone Derivatives of Usnic Acid as Inhibitors of Human TDP1 and TDP2 Enzymes

Tyrosyl-DNA phosphodiesterases 1 and 2 (TDP1 and TDP2) are important DNA repair enzymes that remove various adducts from the 3′- and 5′-ends of DNA, respectively. The suppression of the activity of these enzymes is considered as a promising adjuvant therapy for oncological diseases in combination wi...

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Main Authors: Aleksandr S. Filimonov, Marina A. Mikhailova, Nadezhda S. Dyrkheeva, Irina A. Chernyshova, Tatyana E. Kornienko, Konstantin A. Naumenko, Rashid O. Anarbaev, Andrey A. Nefedov, Chigozie Achara, Anthony D. M. Curtis, Olga A. Luzina, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik, Jóhannes Reynisson
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Chemistry
Subjects:
usnic acid
sulfides
sulfoxide
sulfone
tyrosyl-DNA phosphodiesterase
TDP1 inhibitor
Online Access:https://www.mdpi.com/2624-8549/6/6/101
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