Establishment of an orthotopic tumor model in the mammary gland of BALB/C nude mice using human breast cancer MCF-7 cells and their VDAC-deficient derivatives

Establishment of an orthotopic tumor model in the mammary gland of BALB/C nude mice using human breast cancer MCF-7 cells and their VDAC-deficient derivatives

Purpose to study the tumor-forming activity of wild-type MC F-7 cells carrying a full set of porins (VDAC 1, VDAC 2, VDAC 3), as well as their genetically modified cells, from which one of the isoforms was removed (MC F-7 VDAC 1 KO, MC F-7 VDAC 2 KO, MC F -7 VDAC 3 KO).Material and Methods. The stud...

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Bibliographic Details
Main Authors: E. Yu. Mndlyan, S. G. Semushina, D. I. Rzhevsky, N. I. Novikova, E. A. Kalabina, D. S. Komkov, A. Yu. Maslennikova, A. N. Murashev, E. L. Holmuhamedov
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2022-03-01
Series:Сибирский онкологический журнал
Subjects:
cancer cells mcf-7
mitochondrial porins (vdac1
vdac2
vdac3)
immunodeficient balb / c nude mice
orthotopic tumor
Online Access:https://www.siboncoj.ru/jour/article/view/2029
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