Changes of PGC-1α/TFAM signaling pathway and mitochondrial dysfunction of renal tubular epithelial cells during sepsis-associated acute kidney injury

Changes of PGC-1α/TFAM signaling pathway and mitochondrial dysfunction of renal tubular epithelial cells during sepsis-associated acute kidney injury

Objective To explore the changes of signaling pathways of peroxisome proliferator-activated receptor γ coactivator 1α and mitochondrial transcription factor A and mitochondrial damage in renal tubular epithelial cells during sepsis-associated acute kidney injury（AKI）.Methods A murine model of septic...

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Bibliographic Details
Main Authors: Xiao Zhen-meng, Li Zhi-lian, Dong Wei, Zhang Meng-xi, Chen Yuan-han, Li Rui-zhao, Liang Xin-ling
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Nephrology 2021-01-01
Series:Linchuang shenzangbing zazhi
Subjects:
Sepsis associated acute kidney injury
Peroxisome proliferator-activated receptor γ coactivator 1α
Mitochondrial transcription factor A
Renal tubular epithelial cells
Mitochondrial injury
Online Access:http://www.lcszb.com/thesisDetails?columnId=57904310&Fpath=home&index=0
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