The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis
ABSTRACTThe objective of this study was to assessment the effect of melatonin on lipid profile in rats with experimentally induced acute pancreatitis. In this study, 32 adult, male, healthy Wistar Abino rats were used. Group I animals was no applied. Group II animals was intraperitoneally administer...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2019-09-01
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| Series: | Türk Spor ve Egzersiz Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/811004 |
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| author | Ercan Keskin Deniz Uluışık |
| author_facet | Ercan Keskin Deniz Uluışık |
| author_sort | Ercan Keskin |
| collection | DOAJ |
| description | ABSTRACTThe objective of this study was to assessment
the effect of melatonin on lipid profile in rats with experimentally induced
acute pancreatitis. In this study, 32 adult, male, healthy Wistar Abino rats were
used. Group I animals was no applied.
Group II animals was intraperitoneally administered 50 mg/kg melatonin
per rat twice for two hours intervals. Animals
of group III received two intraperitoneal injections of cerulein (50 µg/kg and
25 µg/kg bw, respectively) at two hours
intervals. Animals of group IV
received two intraperitoneal injections of cerulein (50 µg/kg and 25 µg/kg bw,
respectively) at two hours intervals and
the rats received an intraperitoneal injection of 50 mg/kg melatonin 30 min
before each cerulein injection. After 12
hours from the last cerulein injection, total cholesterol, triglyceride, LDL, HDL
levels was determined. In this study,
experimentally induced acute pancreatitis resulted in significantly increase in
levels of total cholesterol, triglyceride and LDL (p lt;0.05), while HDL level
significantly decreased compared with control group level (p lt;0.05). Pretreatment of melatonin
to the rats with acute pancreatitis importantly reduced triglyceride and LDL
levels compared to pancreatitis group (p lt;0.05). In conclusion, melatonin pretreatment may alleviate
the abnormalities in plasma lipid profile caused by acute pancreatitis. |
| format | Article |
| id | doaj-art-e99197dac0f74997a47a6228794874ba |
| institution | Kabale University |
| issn | 2147-5652 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Türk Spor ve Egzersiz Dergisi |
| spelling | doaj-art-e99197dac0f74997a47a6228794874ba2025-01-03T01:00:31ZengSelcuk University PressTürk Spor ve Egzersiz Dergisi2147-56522019-09-0121233233610.15314/tsed.541829154The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute PancreatitisErcan Keskin0Deniz Uluışık1SELÇUK ÜNİVERSİTESİ, VETERİNER FAKÜLTESİSELÇUK ÜNİVERSİTESİ, VETERİNER FAKÜLTESİABSTRACTThe objective of this study was to assessment the effect of melatonin on lipid profile in rats with experimentally induced acute pancreatitis. In this study, 32 adult, male, healthy Wistar Abino rats were used. Group I animals was no applied. Group II animals was intraperitoneally administered 50 mg/kg melatonin per rat twice for two hours intervals. Animals of group III received two intraperitoneal injections of cerulein (50 µg/kg and 25 µg/kg bw, respectively) at two hours intervals. Animals of group IV received two intraperitoneal injections of cerulein (50 µg/kg and 25 µg/kg bw, respectively) at two hours intervals and the rats received an intraperitoneal injection of 50 mg/kg melatonin 30 min before each cerulein injection. After 12 hours from the last cerulein injection, total cholesterol, triglyceride, LDL, HDL levels was determined. In this study, experimentally induced acute pancreatitis resulted in significantly increase in levels of total cholesterol, triglyceride and LDL (p lt;0.05), while HDL level significantly decreased compared with control group level (p lt;0.05). Pretreatment of melatonin to the rats with acute pancreatitis importantly reduced triglyceride and LDL levels compared to pancreatitis group (p lt;0.05). In conclusion, melatonin pretreatment may alleviate the abnormalities in plasma lipid profile caused by acute pancreatitis.https://dergipark.org.tr/tr/download/article-file/811004ceruleinmelatoninacute pancreatitislipid profile |
| spellingShingle | Ercan Keskin Deniz Uluışık The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis Türk Spor ve Egzersiz Dergisi cerulein melatonin acute pancreatitis lipid profile |
| title | The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis |
| title_full | The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis |
| title_fullStr | The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis |
| title_full_unstemmed | The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis |
| title_short | The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis |
| title_sort | protective effect of melatonin on plasma lipid profile in rats with cerulein induced acute pancreatitis |
| topic | cerulein melatonin acute pancreatitis lipid profile |
| url | https://dergipark.org.tr/tr/download/article-file/811004 |
| work_keys_str_mv | AT ercankeskin theprotectiveeffectofmelatoninonplasmalipidprofileinratswithceruleininducedacutepancreatitis AT denizuluısık theprotectiveeffectofmelatoninonplasmalipidprofileinratswithceruleininducedacutepancreatitis AT ercankeskin protectiveeffectofmelatoninonplasmalipidprofileinratswithceruleininducedacutepancreatitis AT denizuluısık protectiveeffectofmelatoninonplasmalipidprofileinratswithceruleininducedacutepancreatitis |