Suppression of uPA and uPAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines.

Suppression of uPA and uPAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines.

<h4>Background</h4>In our earlier reports, we showed that downregulation of uPA and uPAR inhibited glioma tumor angiogenesis in SNB19 cells, and intraperitoneal injection of a hairpin shRNA expressing plasmid targeting uPA and uPAR inhibited angiogenesis in nude mice. The exact mechanism...

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Main Authors: Hari Raghu, Sajani S Lakka, Christopher S Gondi, Sanjeeva Mohanam, Dzung H Dinh, Meena Gujrati, Jasti S Rao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012458&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012458&type=printable

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