First Report on Cationic Triphenylphosphonium Compounds as Mitochondriotropic H<sub>3</sub>R Ligands with Antioxidant Properties

First Report on Cationic Triphenylphosphonium Compounds as Mitochondriotropic H<sub>3</sub>R Ligands with Antioxidant Properties

Neurodegenerative diseases are a major public health problem due to the aging population and multifaceted pathology; therefore, the search for new therapeutic alternatives is of the utmost importance. In this sense, a series of six 1-(3-phenoxypropyl)piperidines alkyl-linked to a triphenylphosphoniu...

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Bibliographic Details
Main Authors: Tobias Werner, Tito Añazco, Paula Osses-Mendoza, Alejandro Castro-Álvarez, Cristian O. Salas, Raquel Bridi, Holger Stark, Christian Espinosa-Bustos
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Antioxidants
Subjects:
neurodegenerative diseases
antioxidants
histamine 3 receptor
triphenylphosphonium cation
molecular docking
molecular dynamics
Online Access:https://www.mdpi.com/2076-3921/13/11/1345
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