Ivabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cancer

Ivabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cancer

Abstract Background Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targetable proteins for treatment. PARP inhibitors (PARPi) are effective in BRCA-mutated cancers but have limited utility in non-germline BRCA-mutated (non-gBRCAm) TNBC. We hypothesized that inducing BRCAness b...

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Bibliographic Details
Main Authors: Ho Tsoi, George Man Hong Leung, Ellen Pui Sum Man, Chan Ping You, Koei Ho Lam Cheung, Kelvin Yuen Kwong Chan, Chun Gong, Michael Shing Yan Huen, Ui Soon Khoo
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Breast cancer
BRCAness
Ivabradine
Olaparib
Synthetic lethality
Targeted therapy
Online Access:https://doi.org/10.1186/s12967-025-06902-8
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