A Modified Variant of <i>Fasciola hepatica</i> FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

A Modified Variant of <i>Fasciola hepatica</i> FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

Background/Objectives: In the past, FhSAP-2, an 11.5 kDa recombinant protein belonging to the <i>Fasciola hepatica</i> saposin-like/NK-lysin family, has been shown to induce over 60% partial protection in immunized rabbits and mice when challenged with <i>F. hepatica</i> meta...

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Bibliographic Details
Main Authors: Riseilly Ramos-Nieves, Albersy Armina-Rodriguez, Maria Del Mar Figueroa-Gispert, Ghalib Figueroa-Quiñones, Carlimar Ocasio-Malavé, Ana M. Espino
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Vaccines
Subjects:
C57BL6
IgG2a
IgG2c
avidity
FhSAP-2
IFNγ
Online Access:https://www.mdpi.com/2076-393X/13/5/545
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