Connexin 43 suppression enhances contractile force in human iPSC-derived cardiac tissues

Connexin 43 suppression enhances contractile force in human iPSC-derived cardiac tissues

Connexin 43 (Cx43) plays a crucial role in maintaining synchronous contraction in the heart. However, it remains unclear whether Cx43 directly influences the contractile force and synchrony of entire cardiac tissues. Previously, we successfully developed human-induced pluripotent stem cell (hiPSC)-d...

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Main Authors: Takuma Takada, Katsuhisa Matsuura, Tatsuro Iida, Toshiharu Koike, Hidekazu Sekine, Yuhei Higashi, Tsukasa Hara, Daisuke Sasaki, Kyohei Fujita, Yuto Hinata, Junichi Yamaguchi, Tatsuya Shimizu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Connexin 43 (Cx43)
human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
contractility
synchrony
bioengineered cardiac tissues
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1615953/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1615953/full

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