Role of immunosuppressive JNK pathway in the tumor microenvironment among TNBC subtypes in IBCSG trial 22-00

Role of immunosuppressive JNK pathway in the tumor microenvironment among TNBC subtypes in IBCSG trial 22-00

Summary: Phosphorylation of the JNK (pJNK) protein promotes an immunosuppressive tumor microenvironment (TME), enhancing aggressiveness in inflammatory triple-negative breast cancer (TNBC). This study evaluated the role of JNK signaling using a gene signature. RNA sequencing was performed on 347 TNB...

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Main Authors: Andrea Joaquin Garcia, Takashi Semba, Mattia Rediti, Daniel J. McGrail, Xuemei Xie, Xiaoping Wang, Dileep R. Rampa, David Venet, Laurence Buisseret, Samira Majjaj, Roswitha Kammler, Marco Colleoni, Sherene Loi, Giuseppe Viale, Meredith M. Regan, Françoise Rothé, Christos Sotiriou, Naoto T. Ueno
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Immunology
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225012258
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http://www.sciencedirect.com/science/article/pii/S2589004225012258

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