Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4‐2 using proteome arrays

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4‐2 using proteome arrays

Abstract Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2–4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain. The nine Nedd4 family proteins in mammals include two close relatives...

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Bibliographic Details
Main Authors: Avinash Persaud, Philipp Alberts, Eva M Amsen, Xuejian Xiong, James Wasmuth, Zachary Saadon, Chris Fladd, John Parkinson, Daniela Rotin
Format: Article
Language:English
Published: Springer Nature 2009-12-01
Series:Molecular Systems Biology
Subjects:
E3 ubiquitin ligase
HECT domain
Nedd4
proteome array
ubiquitin
Online Access:https://doi.org/10.1038/msb.2009.85
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https://doi.org/10.1038/msb.2009.85

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