Investigations on alloxan-lnduced diabetes in the dogs
In this investigation, nine healthy dogs weighing from 9 to 20 kg were used. The dogs were made diabetic by a single intravenous injection of 0.60-0.70 mmol/kgbw of alloxan, intravenous glucose tolerance tests (IVGTT) were done at the beginning of the study and in the second weeks of alloxan injecti...
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| Language: | English |
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=757 |
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| author | Ali Muhtar Tiftik Kürşat Turgut Mehmet Gürbilek Mutlu Sevinç |
| author_facet | Ali Muhtar Tiftik Kürşat Turgut Mehmet Gürbilek Mutlu Sevinç |
| author_sort | Ali Muhtar Tiftik |
| collection | DOAJ |
| description | In this investigation, nine healthy dogs weighing from 9 to 20 kg were used. The dogs were made diabetic by a single intravenous injection of 0.60-0.70 mmol/kgbw of alloxan, intravenous glucose tolerance tests (IVGTT) were done at the beginning of the study and in the second weeks of alloxan injections.<p>
At the beginning of the study, the mean values of fasted plasma glucose and insulin were found to be 4.56 ± 0.32 mmol/1 and 9.73 ±2.69 m U/ml respectively. After the alloxan injections, clear hyperglycemia and decreasing insulin levels were determined and plasma insulin levels waried between 0-5.33 m U/ml during the study.<p>
In the urinalyses, glucosuria, ketonuria, proteinuria and decreased urinary pH levels were observed in the alloxan diabetic dogs.<p>
After diabetes occured, experimental diets (low high fibre diets) periode was started. Jncreasig plasma glucose levels were determined During the low fibre diet periode whereas decreasing glucose levels determined in the high diet periode.<p>
It is concluded that, it is necessary to apply the IVGTT for the certain diagnosis of diabetes and it is appropriate the recommend of rye bread for the regulation of hyperglycemia. |
| format | Article |
| id | doaj-art-e7e2a48b81aa4c5f8995a95e64c9f281 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-e7e2a48b81aa4c5f8995a95e64c9f2812025-01-02T22:35:07ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-1953821821757Investigations on alloxan-lnduced diabetes in the dogsAli Muhtar Tiftik0Kürşat Turgut1Mehmet Gürbilek2Mutlu Sevinç3Yrd. Doç. Dr., S. Ü. Vet. Fak. Biyokimya Anabilim Dalı, KonyaDoç. Dr., S. Ü. Vet. Fak. İç Hastalıkları Anabilim Dalı, KonyaUzman, S. Ü. Tıp Fak. Biyokimya Anabilim Dalı, KonyaAraş. Gör., S. Ü. Vet. Fak. İç Hastalıkları Anabilim Dalı, KonyaIn this investigation, nine healthy dogs weighing from 9 to 20 kg were used. The dogs were made diabetic by a single intravenous injection of 0.60-0.70 mmol/kgbw of alloxan, intravenous glucose tolerance tests (IVGTT) were done at the beginning of the study and in the second weeks of alloxan injections.<p> At the beginning of the study, the mean values of fasted plasma glucose and insulin were found to be 4.56 ± 0.32 mmol/1 and 9.73 ±2.69 m U/ml respectively. After the alloxan injections, clear hyperglycemia and decreasing insulin levels were determined and plasma insulin levels waried between 0-5.33 m U/ml during the study.<p> In the urinalyses, glucosuria, ketonuria, proteinuria and decreased urinary pH levels were observed in the alloxan diabetic dogs.<p> After diabetes occured, experimental diets (low high fibre diets) periode was started. Jncreasig plasma glucose levels were determined During the low fibre diet periode whereas decreasing glucose levels determined in the high diet periode.<p> It is concluded that, it is necessary to apply the IVGTT for the certain diagnosis of diabetes and it is appropriate the recommend of rye bread for the regulation of hyperglycemia.http://eurasianjvetsci.org/pdf.php3?id=757 |
| spellingShingle | Ali Muhtar Tiftik Kürşat Turgut Mehmet Gürbilek Mutlu Sevinç Investigations on alloxan-lnduced diabetes in the dogs Eurasian Journal of Veterinary Sciences |
| title | Investigations on alloxan-lnduced diabetes in the dogs |
| title_full | Investigations on alloxan-lnduced diabetes in the dogs |
| title_fullStr | Investigations on alloxan-lnduced diabetes in the dogs |
| title_full_unstemmed | Investigations on alloxan-lnduced diabetes in the dogs |
| title_short | Investigations on alloxan-lnduced diabetes in the dogs |
| title_sort | investigations on alloxan lnduced diabetes in the dogs |
| url | http://eurasianjvetsci.org/pdf.php3?id=757 |
| work_keys_str_mv | AT alimuhtartiftik investigationsonalloxanlnduceddiabetesinthedogs AT kursatturgut investigationsonalloxanlnduceddiabetesinthedogs AT mehmetgurbilek investigationsonalloxanlnduceddiabetesinthedogs AT mutlusevinc investigationsonalloxanlnduceddiabetesinthedogs |