Ferroptosis and Charcot–Marie–Tooth Disease 1A: Emerging Evidence for a Pathogenic Association

Ferroptosis and Charcot–Marie–Tooth Disease 1A: Emerging Evidence for a Pathogenic Association

Charcot–Marie–Tooth disease (CMT) is the most common hereditary peripheral neuropathy worldwide, presenting clinically as muscle weakness that progresses to impaired ambulation or quadriplegia with age. CMT1A, the most common subtype, is caused by a duplication in PMP22, encoding an essential membra...

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Bibliographic Details
Main Authors: Jacob B. White, Kayla L. Sanchez, Antonio Currais, David Soriano-Castell, Pamela Maher, Salvador Soriano
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Antioxidants
Subjects:
Charcot–Marie–Tooth
CMT1A
ferroptosis
peripheral neuropathy
oxidative stress
ferroptotic stress
Online Access:https://www.mdpi.com/2076-3921/14/3/331
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