A proteotranscriptomic approach to dissect the molecular landscape of human retinoblastoma

A proteotranscriptomic approach to dissect the molecular landscape of human retinoblastoma

BackgroundRetinoblastoma is a rare pediatric eye cancer caused by mutations in the RB1 gene, which regulates retinal cell growth. Early detection and treatment are critical for preventing vision loss and improving survival outcomes. This study aimed to perform an integrated proteotranscriptomic char...

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Main Authors: Julian Wolf, Rozina Ida Hajdu, Stefaniya Boneva, Ira Godbole, Lucas Stürzbecher, Claudia Auw-Haedrich, Wolf A. Lagrèze, Hansjürgen Agostini, Thomas Reinhard, Stefan Tholen, Oliver Schilling, Günther Schlunck, Bertram Bengsch, Clemens Lange
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
retinoblastoma
transcriptomics
proteomics
IMC
proteotranscriptomics
translational medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1571702/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1571702/full

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