In vitro and in vivo antifungal activity of Minocycline albumin nanoparticles in combination with fluconazole against azole-resistant Candida spp

In vitro and in vivo antifungal activity of Minocycline albumin nanoparticles in combination with fluconazole against azole-resistant Candida spp

Abstract Despite the widespread use of fluconazole (FLC) in treating Candida infections, the emergence of drug resistance has become an increasing concern. Our earlier studies showing synergism between minocycline (Min) and azoles were limited by Min’s high required concentrations exceeding clinical...

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Bibliographic Details
Main Authors: Lulu An, Xiaowen Huang, Meizhen Zhong, Jiaan Wu, Mei Liu, Liqian Geng, Yongyong Li, Xiuli Wang, Lianjuan Yang, Jingwen Tan
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Microbiology
Subjects:
Minocycline
Albumin nanoparticles
Fluconazole
Synergistic effect
Candida spp
Online Access:https://doi.org/10.1186/s12866-025-04230-x
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https://doi.org/10.1186/s12866-025-04230-x

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