Regulatory role of LncRNA FMR1-AS1 in the pathogenesis of alzheimer’s disease based on bioinformatics and in vitro experimental validation

Regulatory role of LncRNA FMR1-AS1 in the pathogenesis of alzheimer’s disease based on bioinformatics and in vitro experimental validation

Abstract Alzheimer’s disease (AD) is a major cause of dementia, characterized by $$\beta$$ -amyloid (A $$\beta$$ ) plaque accumulation and Tau protein hyperphosphorylation. Although long non-coding RNAs (lncRNAs) have been implicated in neurodegenerative diseases, their roles in AD remain unclear. T...

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Bibliographic Details
Main Authors: Xiang Yu, Hao Cai, Cai He, Zhong Ouyang, Yongchang Li, Liang Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
FMR1-AS1
A $$\beta$$ 1–42
Neuronal cells
Oxidative stress
Tau phosphorylation
Online Access:https://doi.org/10.1038/s41598-025-15242-y
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https://doi.org/10.1038/s41598-025-15242-y

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