Macrophagic Ym1 orchestrates γδT cell-derived IL-17 production and keratinocyte functionality to mediate psoriasis-like skin inflammation

Macrophagic Ym1 orchestrates γδT cell-derived IL-17 production and keratinocyte functionality to mediate psoriasis-like skin inflammation

Abstract Psoriasis is a chronic inflammatory skin disease, with the IL-17 pathway being a key contributor. Ym1, a positionally cloned inflammation regulatory gene linked to various disorders, has an unclear effect on skin inflammation. In this study, the role of Ym1 was investigated in both mannan a...

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Bibliographic Details
Main Authors:	Wentao Zhang, Fei Li, Yu Wang, Meiyang Fan, Yan Zhao, Yanglong Guan, Yan Zhou, Shemin Lu, Rikard Holmdahl, Liesu Meng, Wenhua Zhu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-025-08628-1
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