Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer

Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer

Abstract Ferroptosis induced by ferrous ions (Fe2+) and lipid peroxidation accumulation is a novel form of regulated cell death that has become a hot topic in tumor therapy research. Identifying small-molecule drugs that can induce ferroptosis in tumor cells is a very attractive therapeutic strategy...

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Main Authors: Dianping Yu, Hongmei Hu, Qing Zhang, Chengji Wang, Mengting Xu, Hanchen Xu, Xiangxin Geng, Minchen Cai, Hongwei Zhang, Mengmeng Guo, Dong Lu, Hanchi Xu, Linyang Li, Xing Zhang, Ruling Shen, Sheng Lin, Qun Wang, Weidong Zhang, Sanhong Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02296-7
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https://doi.org/10.1038/s41392-025-02296-7

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