A review of recent Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypes
Cryptosporidium spp. are known to cause gastroenteritis (cryptosporidiosis) in numerous hosts, including humans. Understanding the diversity within this genus of parasites requires accurate subtyping, which is frequently performed by sequencing part of the gp60 (60-kDa glycoprotein) gene. This liter...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Current Research in Parasitology and Vector-Borne Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667114X25000524 |
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| author | Deborah B. Oladele Martin Swain Guy Robinson Amanda Clare Rachel M. Chalmers |
| author_facet | Deborah B. Oladele Martin Swain Guy Robinson Amanda Clare Rachel M. Chalmers |
| author_sort | Deborah B. Oladele |
| collection | DOAJ |
| description | Cryptosporidium spp. are known to cause gastroenteritis (cryptosporidiosis) in numerous hosts, including humans. Understanding the diversity within this genus of parasites requires accurate subtyping, which is frequently performed by sequencing part of the gp60 (60-kDa glycoprotein) gene. This literature review examines Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypes reported between December 2018 and January 2024 in humans, livestock, and non-human primates (NHPs). The review highlights emerging trends in the subtypes reported and reveals the shifting dominance of subtype families, which can be influenced by factors such as anthroponotic interactions. The C. parvum IIa and IId families remain major contributors to infections across a variety of hosts, with recent reports indicating the continued emergence of the IId family. Furthermore, previously established and newly reported subtypes detected in NHPs highlight the potential for genetic recombination between human-adapted and NHP-adapted subtypes. |
| format | Article |
| id | doaj-art-e744d03ce6f149209e8e3105dc17d2f7 |
| institution | Kabale University |
| issn | 2667-114X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Parasitology and Vector-Borne Diseases |
| spelling | doaj-art-e744d03ce6f149209e8e3105dc17d2f72025-08-20T03:55:53ZengElsevierCurrent Research in Parasitology and Vector-Borne Diseases2667-114X2025-01-01810029210.1016/j.crpvbd.2025.100292A review of recent Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypesDeborah B. Oladele0Martin Swain1Guy Robinson2Amanda Clare3Rachel M. Chalmers4Department of Life Sciences, Aberystwyth University, Penglais, Aberystwyth, Ceredigion, SY23 3DA, UK; Corresponding author.Department of Life Sciences, Aberystwyth University, Penglais, Aberystwyth, Ceredigion, SY23 3DA, UKCryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital, Sgeti, Swansea, SA2 8QA, UK; Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UKDepartment of Life Sciences, Aberystwyth University, Penglais, Aberystwyth, Ceredigion, SY23 3DA, UKCryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital, Sgeti, Swansea, SA2 8QA, UK; Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UKCryptosporidium spp. are known to cause gastroenteritis (cryptosporidiosis) in numerous hosts, including humans. Understanding the diversity within this genus of parasites requires accurate subtyping, which is frequently performed by sequencing part of the gp60 (60-kDa glycoprotein) gene. This literature review examines Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypes reported between December 2018 and January 2024 in humans, livestock, and non-human primates (NHPs). The review highlights emerging trends in the subtypes reported and reveals the shifting dominance of subtype families, which can be influenced by factors such as anthroponotic interactions. The C. parvum IIa and IId families remain major contributors to infections across a variety of hosts, with recent reports indicating the continued emergence of the IId family. Furthermore, previously established and newly reported subtypes detected in NHPs highlight the potential for genetic recombination between human-adapted and NHP-adapted subtypes.http://www.sciencedirect.com/science/article/pii/S2667114X25000524Cryptosporidiumgp60SubtypingNHPZoonoticAnthroponotic |
| spellingShingle | Deborah B. Oladele Martin Swain Guy Robinson Amanda Clare Rachel M. Chalmers A review of recent Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypes Current Research in Parasitology and Vector-Borne Diseases Cryptosporidium gp60 Subtyping NHP Zoonotic Anthroponotic |
| title | A review of recent Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypes |
| title_full | A review of recent Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypes |
| title_fullStr | A review of recent Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypes |
| title_full_unstemmed | A review of recent Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypes |
| title_short | A review of recent Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypes |
| title_sort | review of recent cryptosporidium hominis and cryptosporidium parvum gp60 subtypes |
| topic | Cryptosporidium gp60 Subtyping NHP Zoonotic Anthroponotic |
| url | http://www.sciencedirect.com/science/article/pii/S2667114X25000524 |
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