Hyperoxia shows duration-dependent effects on the lengths of cell cycle phases in fetal cortical neural stem cells

Hyperoxia shows duration-dependent effects on the lengths of cell cycle phases in fetal cortical neural stem cells

Fetal neural stem cells (NSCs) physiologically reside under low-oxygen conditions (1%–5% of tissue pO2), but are often transferred and maintained under atmospheric oxygen levels of 21% pO2 (hyperoxia) for in vitro investigations. These altered oxygen conditions lead to adaptive changes in NSCs which...

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Bibliographic Details
Main Authors: Jennifer Lanto, Monika Maria Nicole Vehlken, Valeriia Abramenko, Alexander Storch, Franz Markert
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
oxygen
neural stem cells
hypoxia
hyperoxia
physioxia
cortex
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1546131/full
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