Grape seed extract and L-ascorbic acid exert antineoplastic effects against solid Ehrlich carcinoma in vivo by modulating the tumor microenvironment and Th1/Th2 balance

Grape seed extract and L-ascorbic acid exert antineoplastic effects against solid Ehrlich carcinoma in vivo by modulating the tumor microenvironment and Th1/Th2 balance

ObjectiveThe existing study sought to highlight the modulatory effect of co-treatment based on grape seed extract (GSE) and L. ascorbic acid (AA) on tumor microenvironment and immune response in murine solid Ehrlich carcinoma (SEC). MethodsGSE (200 mg / kg; orally) and AA (50 mg/ kg; orally) were gi...

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Main Authors: Dalia S. Morsi, Heba M. R. Hathout, Hind S. AboShabaan, Mahmoud Emam, Manal El-khadragy, Ahmed E. Abdel Moneim, Islam M. El-Garawani, Hagar A. Abu Quora
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
grape seed
vitamin C
solid ehrlich carcinoma
tumor immune microenvironment
Th/Th2 balance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1635071/full
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