N-terminus α-synuclein detection reveals new and more diverse aggregate morphologies in multiple system atrophy and Parkinson’s disease

N-terminus α-synuclein detection reveals new and more diverse aggregate morphologies in multiple system atrophy and Parkinson’s disease

Abstract Background Parkinson’s disease (PD) and multiple system atrophy (MSA) are classified as α-synucleinopathies and are primarily differentiated by their clinical phenotypes. Delineating these diseases based on their specific α-synuclein (α-Syn) proteoform pathologies is crucial for accurate an...

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Bibliographic Details
Main Authors: James A. Wiseman, YuHong Fu, Richard L. M. Faull, Clinton P. Turner, Maurice A. Curtis, Glenda M. Halliday, Birger V. Dieriks
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Translational Neurodegeneration
Subjects:
α-Synuclein
Lewy body diseases
Parkinson’s disease
Multiple system atrophy
N-terminus
Epitope-specific
Online Access:https://doi.org/10.1186/s40035-024-00456-3
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https://doi.org/10.1186/s40035-024-00456-3

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