eIF5A downregulated by mechanical overloading delays chondrocyte senescence and osteoarthritis by regulating the CREBBP-mediated Notch pathway

eIF5A downregulated by mechanical overloading delays chondrocyte senescence and osteoarthritis by regulating the CREBBP-mediated Notch pathway

Aims: To examine how eukaryotic translation initiation factor 5A (eIF5A) regulates osteoarthritis (OA) during mechanical overload and the specific mechanism. Methods: Histological experiments used human bone samples and C57BL/6J mice knee samples. All cell experiments were performed using mice pri...

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Bibliographic Details
Main Authors: Jialuo Huang, Jianrong Zheng, Jianbin Yin, Rengui Lin, Junfeng Wu, Hao-Ran Xu, Jinjian Zhu, Haiyan Zhang, Guiqing Wang, Daozhang Cai
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2025-02-01
Series:Bone & Joint Research
Subjects:
osteoarthritis
chondrocytes
eif5a
mechanical stress
crebbp
osteoarthritis (oa)
matrix metalloproteinase 13
staining
quantitative polymerase chain reaction
strain
western blot
collagen
fast green staining
cartilage
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.142.BJR-2024-0288.R1
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https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.142.BJR-2024-0288.R1

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