FBXW7 in gastrointestinal cancers: from molecular mechanisms to therapeutic prospects

FBXW7 in gastrointestinal cancers: from molecular mechanisms to therapeutic prospects

F-box and WD repeat domain-containing 7 (FBXW7), formerly known as hCdc4, hAGO Fbw7, or SEL10, plays a specific recognition function in SCF-type E3 ubiquitin ligases. FBXW7 is a well-established cancer suppressor gene that specifically controls proteasomal degradation and destruction of many key onc...

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Bibliographic Details
Main Authors: Wanqing Wang, Xue Liu, Lingling Zhao, Kaipeng Jiang, Ziyi Yu, Ruihan Yang, Wenshuo Zhou, Jiuwei Cui, Tingting Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
FBXW7
gastrointestinal cancers
molecular mechanism
therapeutic strategies
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1505027/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1505027/full

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