Bone morphogenetic proteins, DNA methylation, and gut microbiota interaction in lumbar disc degeneration: A multi‐omics Mendelian randomization study

Bone morphogenetic proteins, DNA methylation, and gut microbiota interaction in lumbar disc degeneration: A multi‐omics Mendelian randomization study

Abstract Background Lumbar disc degeneration (LDD) is a ubiquitous finding in low back pain. Many different etiology factors may explain the LDD process, such as bone morphogenetic proteins (BMPs), DNA methylation, and gut microbiota. Until recently the mechanisms underlying the LDD process have bee...

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Bibliographic Details
Main Authors: Xiang‐Yu Li, Peng‐Yun Wang, Qi‐Jun Wang, Dong‐Fan Wang, Shuai‐Kang Wang, Yu Wang, Wei‐Guo Zhu, Wei Wang, Chao Kong, Shi‐Bao Lu, Xiao‐Long Chen
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:JOR Spine
Subjects:
bone morphogenetic proteins
gut microbiota
integrative omics
lumbar disc degeneration
Mendelian randomization
Online Access:https://doi.org/10.1002/jsp2.70027
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https://doi.org/10.1002/jsp2.70027

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