Mass cytometry: exploring the immune landscape of systemic autoimmune and inflammatory diseases in the past fourteen years
Auto-immune and inflammatory diseases are heterogenous in their clinical manifestations and prognosis, even among individuals presenting with the same pathology. Understanding the immunological alterations involved in their pathogenesis provides valuable insights in different clinical phenotypes and...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1509782/full |
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| author | Aïcha Kante Aïcha Kante Mathieu F. Chevalier Damien Sène Damien Sène Jeanne Chauffier Jeanne Chauffier Stéphane Mouly Stéphane Mouly Benjamin Glenn Chousterman Benjamin Glenn Chousterman Fériel Azibani Benjamin Terrier Benjamin Terrier Théo Pezel Théo Pezel Cloé Comarmond Cloé Comarmond |
| author_facet | Aïcha Kante Aïcha Kante Mathieu F. Chevalier Damien Sène Damien Sène Jeanne Chauffier Jeanne Chauffier Stéphane Mouly Stéphane Mouly Benjamin Glenn Chousterman Benjamin Glenn Chousterman Fériel Azibani Benjamin Terrier Benjamin Terrier Théo Pezel Théo Pezel Cloé Comarmond Cloé Comarmond |
| author_sort | Aïcha Kante |
| collection | DOAJ |
| description | Auto-immune and inflammatory diseases are heterogenous in their clinical manifestations and prognosis, even among individuals presenting with the same pathology. Understanding the immunological alterations involved in their pathogenesis provides valuable insights in different clinical phenotypes and treatment responses. Immunophenotyping could lead to significant improvements in diagnosis, monitoring, initial treatment decisions and follow-up in autoimmune and inflammatory diseases. Mass cytometry provides measurement of over 40 simultaneous cellular parameters at single-cell resolution, and therefore holds immense potential to evaluate complex cellular systems and for high-dimensional single-cell analysis. The high dimensionality of mass cytometry provides better coverage of immune populations dynamics, with sufficient power to identify rare cell types compared to flow cytometry. In this comprehensive review, we explore how mass cytometry findings contributed in the past decade to a deeper understanding of the cellular actors involved in systemic auto-immune and auto-inflammatory diseases with their respective therapeutic and prognostic impact. We also delve into the bioinformatical approaches applied to mass cytometry to analyze the high volumes of data generated, as well as the impact of the use of complementary single cell RNA sequencing, and their spatial modalities. Our analysis highlights the fact that mass cytometry captures major information on cell populations providing insights on the complex pathogenesis of autoimmune diseases. Future research designs could include mass cytometry findings in association to other -omics to stratify patients in adequate therapeutic arms and provide advancements in personalized therapies in the field of auto-immune and inflammatory diseases. |
| format | Article |
| id | doaj-art-e5f569860dca4a05a6382b957b66092f |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e5f569860dca4a05a6382b957b66092f2025-01-17T05:10:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15097821509782Mass cytometry: exploring the immune landscape of systemic autoimmune and inflammatory diseases in the past fourteen yearsAïcha Kante0Aïcha Kante1Mathieu F. Chevalier2Damien Sène3Damien Sène4Jeanne Chauffier5Jeanne Chauffier6Stéphane Mouly7Stéphane Mouly8Benjamin Glenn Chousterman9Benjamin Glenn Chousterman10Fériel Azibani11Benjamin Terrier12Benjamin Terrier13Théo Pezel14Théo Pezel15Cloé Comarmond16Cloé Comarmond17Department of Internal Medicine, Lariboisière Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, FranceINSERM UMR-S 976, Institut de Recherche Saint-Louis, Université Paris Cité, Paris, FranceINSERM UMR-S 976, Institut de Recherche Saint-Louis, Université Paris Cité, Paris, FranceDepartment of Internal Medicine, Lariboisière Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, FranceINSERM UMR-S 976, Institut de Recherche Saint-Louis, Université Paris Cité, Paris, FranceDepartment of Internal Medicine, Lariboisière Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, FranceINSERM UMR-S 976, Institut de Recherche Saint-Louis, Université Paris Cité, Paris, FranceDepartment of Internal Medicine, Lariboisière Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, FranceINSERM UMR-S 1144, Université Paris Cité, Paris, FranceDepartment of Anesthesiology and Intensive Care, Lariboisière Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, FranceINSERM UMR-S 942 MASCOT - Université Paris Cité, Paris, FranceINSERM UMR-S 942 MASCOT - Université Paris Cité, Paris, FranceDepartment of Internal Medicine, Cochin Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, FranceINSERM, U970, PARCC, Université de Paris Cité, Paris, FranceINSERM UMR-S 942 MASCOT - Université Paris Cité, Paris, FranceDepartment of Cardiology, Lariboisière Hospital, Université Paris Cité, Paris, FranceDepartment of Internal Medicine, Lariboisière Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, FranceINSERM UMR-S 976, Institut de Recherche Saint-Louis, Université Paris Cité, Paris, FranceAuto-immune and inflammatory diseases are heterogenous in their clinical manifestations and prognosis, even among individuals presenting with the same pathology. Understanding the immunological alterations involved in their pathogenesis provides valuable insights in different clinical phenotypes and treatment responses. Immunophenotyping could lead to significant improvements in diagnosis, monitoring, initial treatment decisions and follow-up in autoimmune and inflammatory diseases. Mass cytometry provides measurement of over 40 simultaneous cellular parameters at single-cell resolution, and therefore holds immense potential to evaluate complex cellular systems and for high-dimensional single-cell analysis. The high dimensionality of mass cytometry provides better coverage of immune populations dynamics, with sufficient power to identify rare cell types compared to flow cytometry. In this comprehensive review, we explore how mass cytometry findings contributed in the past decade to a deeper understanding of the cellular actors involved in systemic auto-immune and auto-inflammatory diseases with their respective therapeutic and prognostic impact. We also delve into the bioinformatical approaches applied to mass cytometry to analyze the high volumes of data generated, as well as the impact of the use of complementary single cell RNA sequencing, and their spatial modalities. Our analysis highlights the fact that mass cytometry captures major information on cell populations providing insights on the complex pathogenesis of autoimmune diseases. Future research designs could include mass cytometry findings in association to other -omics to stratify patients in adequate therapeutic arms and provide advancements in personalized therapies in the field of auto-immune and inflammatory diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1509782/fullmass cytometryCyTOFimaging mass cytometrysystemic autoimmune diseasessystemic inflammatory diseasessingle-cell |
| spellingShingle | Aïcha Kante Aïcha Kante Mathieu F. Chevalier Damien Sène Damien Sène Jeanne Chauffier Jeanne Chauffier Stéphane Mouly Stéphane Mouly Benjamin Glenn Chousterman Benjamin Glenn Chousterman Fériel Azibani Benjamin Terrier Benjamin Terrier Théo Pezel Théo Pezel Cloé Comarmond Cloé Comarmond Mass cytometry: exploring the immune landscape of systemic autoimmune and inflammatory diseases in the past fourteen years Frontiers in Immunology mass cytometry CyTOF imaging mass cytometry systemic autoimmune diseases systemic inflammatory diseases single-cell |
| title | Mass cytometry: exploring the immune landscape of systemic autoimmune and inflammatory diseases in the past fourteen years |
| title_full | Mass cytometry: exploring the immune landscape of systemic autoimmune and inflammatory diseases in the past fourteen years |
| title_fullStr | Mass cytometry: exploring the immune landscape of systemic autoimmune and inflammatory diseases in the past fourteen years |
| title_full_unstemmed | Mass cytometry: exploring the immune landscape of systemic autoimmune and inflammatory diseases in the past fourteen years |
| title_short | Mass cytometry: exploring the immune landscape of systemic autoimmune and inflammatory diseases in the past fourteen years |
| title_sort | mass cytometry exploring the immune landscape of systemic autoimmune and inflammatory diseases in the past fourteen years |
| topic | mass cytometry CyTOF imaging mass cytometry systemic autoimmune diseases systemic inflammatory diseases single-cell |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1509782/full |
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