Clinical Efficacy of Pneumococcal Conjugate 13-valent Vaccine in Young Children
Objective: Our aim was to study the clinical efficacy of pneumococcal conjugate 13-valent vaccine (PCV13) in children aged less than 3 years.Methods: retrospective comparative study of the incidence of acute respiratory infections (ARI), otitis and pneumonia during the first three years of life in 1...
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| Format: | Article |
| Language: | Russian |
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Union of pediatricians of Russia
2016-12-01
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| Series: | Педиатрическая фармакология |
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| Online Access: | https://www.pedpharma.ru/jour/article/view/1462 |
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| author | S. M. Kharit I. V. Fridman A. N. Pavlyukova E. Ya. Frolova A. A. Ruleva |
| author_facet | S. M. Kharit I. V. Fridman A. N. Pavlyukova E. Ya. Frolova A. A. Ruleva |
| author_sort | S. M. Kharit |
| collection | DOAJ |
| description | Objective: Our aim was to study the clinical efficacy of pneumococcal conjugate 13-valent vaccine (PCV13) in children aged less than 3 years.Methods: retrospective comparative study of the incidence of acute respiratory infections (ARI), otitis and pneumonia during the first three years of life in 184 children vaccinated with PKV13 and 186 unvaccinated peers.Results: 91 of 184 children (49.4%) were vaccinated during the 1st year of life, 61 (33.2%) — during the 2nd year, and 32 (17.4%) — during the 3rd year. Number of ARI per 1 child among children vaccinated in the 1st year of life was 5.5 times less than among unvaccinated children (0.42 and 2.31 cases); frequency of otitis during the second year of life was 6.8 times less (7.6% and 52.1%, р < 0,01), and during the third — 34.7 times less (1.1% and 38.2%, р < 0,01). All children vaccinated before the age of 1 were 6.3 times less (1.1% and 6.9%) ill with pneumonias. Additionally it was noted that number of ARI per 1 person among children, vaccinated during the 1st year of life, during the third year of life was lower than among children vaccinated later (0.42; 1.02; 2.03 respectively). There also was a significant in otitis number between children vaccinated during the first and the third years of life (1.1 and 15.6% р < 0,01).Conclusion: to reduce the incidence of ARI, otitis and pneumonia in children, it is necessary to vaccinate children with PCV13 in the age under 1 year. «Catching up» immunization of the second and third years of life is effective, but to a lesser extent. |
| format | Article |
| id | doaj-art-e5f26cd2bc294a348adcc1cb7cb610e9 |
| institution | Kabale University |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2016-12-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-e5f26cd2bc294a348adcc1cb7cb610e92025-08-20T03:59:21ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892016-12-0113544344710.15690/pf.v13i5.16391440Clinical Efficacy of Pneumococcal Conjugate 13-valent Vaccine in Young ChildrenS. M. Kharit0I. V. Fridman1A. N. Pavlyukova2E. Ya. Frolova3A. A. Ruleva4Russian Federal Biomedical Agency’s Research Institute of Children’s Infections Saint-Petersburg State Pediatric Medical UniversityRussian Federal Biomedical Agency’s Research Institute of Children’s InfectionsPreventive clinic № 30 children’s outpatient department №2 of the Primorsky district of St. PetersburgRostropovich-Vishnevskaya FoundationRussian Federal Biomedical Agency’s Research Institute of Children’s InfectionsObjective: Our aim was to study the clinical efficacy of pneumococcal conjugate 13-valent vaccine (PCV13) in children aged less than 3 years.Methods: retrospective comparative study of the incidence of acute respiratory infections (ARI), otitis and pneumonia during the first three years of life in 184 children vaccinated with PKV13 and 186 unvaccinated peers.Results: 91 of 184 children (49.4%) were vaccinated during the 1st year of life, 61 (33.2%) — during the 2nd year, and 32 (17.4%) — during the 3rd year. Number of ARI per 1 child among children vaccinated in the 1st year of life was 5.5 times less than among unvaccinated children (0.42 and 2.31 cases); frequency of otitis during the second year of life was 6.8 times less (7.6% and 52.1%, р < 0,01), and during the third — 34.7 times less (1.1% and 38.2%, р < 0,01). All children vaccinated before the age of 1 were 6.3 times less (1.1% and 6.9%) ill with pneumonias. Additionally it was noted that number of ARI per 1 person among children, vaccinated during the 1st year of life, during the third year of life was lower than among children vaccinated later (0.42; 1.02; 2.03 respectively). There also was a significant in otitis number between children vaccinated during the first and the third years of life (1.1 and 15.6% р < 0,01).Conclusion: to reduce the incidence of ARI, otitis and pneumonia in children, it is necessary to vaccinate children with PCV13 in the age under 1 year. «Catching up» immunization of the second and third years of life is effective, but to a lesser extent.https://www.pedpharma.ru/jour/article/view/1462childrenpneumococcal infectionvaccinationconjugated 13-valent vaccineacute respiratory infectionotitispneumonia |
| spellingShingle | S. M. Kharit I. V. Fridman A. N. Pavlyukova E. Ya. Frolova A. A. Ruleva Clinical Efficacy of Pneumococcal Conjugate 13-valent Vaccine in Young Children Педиатрическая фармакология children pneumococcal infection vaccination conjugated 13-valent vaccine acute respiratory infection otitis pneumonia |
| title | Clinical Efficacy of Pneumococcal Conjugate 13-valent Vaccine in Young Children |
| title_full | Clinical Efficacy of Pneumococcal Conjugate 13-valent Vaccine in Young Children |
| title_fullStr | Clinical Efficacy of Pneumococcal Conjugate 13-valent Vaccine in Young Children |
| title_full_unstemmed | Clinical Efficacy of Pneumococcal Conjugate 13-valent Vaccine in Young Children |
| title_short | Clinical Efficacy of Pneumococcal Conjugate 13-valent Vaccine in Young Children |
| title_sort | clinical efficacy of pneumococcal conjugate 13 valent vaccine in young children |
| topic | children pneumococcal infection vaccination conjugated 13-valent vaccine acute respiratory infection otitis pneumonia |
| url | https://www.pedpharma.ru/jour/article/view/1462 |
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