Wolfram syndrome 2 gene (CISD2) deficiency disrupts Ca2+-mediated insulin secretion in β-cells

Wolfram syndrome 2 gene (CISD2) deficiency disrupts Ca2+-mediated insulin secretion in β-cells

Objective: Diabetes, characterized by childhood-onset, autoantibody-negativity and insulin-deficiency, is a major manifestation of Wolfram syndrome 2 (WFS2), which is caused by recessive mutations of CISD2. Nevertheless, the mechanism underlying β-cell dysfunction in WFS2 remains elusive. Here we de...

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Bibliographic Details
Main Authors: Zhao-Qing Shen, Wen-Tai Chiu, Cheng-Heng Kao, Yu-Chen Chen, Li-Hsien Chen, Tsai-Wen Teng, Shao-Yu Hsiung, Tsai-Yu Tzeng, Chien-Yi Tung, Chi-Chang Juan, Ting-Fen Tsai
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Metabolism
Subjects:
CISD2
Wolfram syndrome 2
Diabetes
Ca2+ homeostasis
Mitochondrial function
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782500047X
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