Chromatographic and spectroscopic studies on β-cyclodextrin functionalized ionic liquid as chiral stationary phase: Enantioseparation of NSAIDs
Recently, we reported a new chiral stationary phase prepared using β-cyclodextrin functionalized with aromatic ionic liquid which is aimed to enhance the performance of enantioseparation of flavonoids and β-blockers. In this paper, the characteristics and performance of previously prepared chiral st...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-02-01
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| Series: | Adsorption Science & Technology |
| Online Access: | https://doi.org/10.1177/0263617416686798 |
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| author | Nurul Yani Rahim Kheng Soo Tay Sharifah Mohamad |
| author_facet | Nurul Yani Rahim Kheng Soo Tay Sharifah Mohamad |
| author_sort | Nurul Yani Rahim |
| collection | DOAJ |
| description | Recently, we reported a new chiral stationary phase prepared using β-cyclodextrin functionalized with aromatic ionic liquid which is aimed to enhance the performance of enantioseparation of flavonoids and β-blockers. In this paper, the characteristics and performance of previously prepared chiral stationary phase denoted as β-CD-BIMOTs were compared with the newly synthesized chiral stationary phase denoted as β-CD-DIMOTs. β-CD-DIMOTs were prepared by functionalization of β-cyclodextrin with aliphatic ionic liquid. The obtained β-CD-BIMOTs and β-CD-DIMOTs stationary phases were compared with native β-CD stationary phase for the enantioseparation of non-steroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, indoprofen, ketoprofen and fenoprofen). The β-CD-BIMOTs stationary phase showed greater chiral resolution capabilities rather than β-CD-DIMOTs and native β-CD stationary phases. Further, in order to understand the interaction of enantioseparation, the inclusion complex formation between NSAIDs and β-CD-BIMOTs was studied using 1 H NMR, NOESY and UV/Vis. The enantioseparated NSAIDs were found to form multiple interactions with β-CD-BIMOTs-CSP. |
| format | Article |
| id | doaj-art-e5c8b7b6698340a1b31f2337e5ae5a91 |
| institution | Kabale University |
| issn | 0263-6174 2048-4038 |
| language | English |
| publishDate | 2018-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Adsorption Science & Technology |
| spelling | doaj-art-e5c8b7b6698340a1b31f2337e5ae5a912025-01-02T23:11:48ZengSAGE PublishingAdsorption Science & Technology0263-61742048-40382018-02-013610.1177/0263617416686798Chromatographic and spectroscopic studies on β-cyclodextrin functionalized ionic liquid as chiral stationary phase: Enantioseparation of NSAIDsNurul Yani RahimKheng Soo TaySharifah MohamadRecently, we reported a new chiral stationary phase prepared using β-cyclodextrin functionalized with aromatic ionic liquid which is aimed to enhance the performance of enantioseparation of flavonoids and β-blockers. In this paper, the characteristics and performance of previously prepared chiral stationary phase denoted as β-CD-BIMOTs were compared with the newly synthesized chiral stationary phase denoted as β-CD-DIMOTs. β-CD-DIMOTs were prepared by functionalization of β-cyclodextrin with aliphatic ionic liquid. The obtained β-CD-BIMOTs and β-CD-DIMOTs stationary phases were compared with native β-CD stationary phase for the enantioseparation of non-steroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, indoprofen, ketoprofen and fenoprofen). The β-CD-BIMOTs stationary phase showed greater chiral resolution capabilities rather than β-CD-DIMOTs and native β-CD stationary phases. Further, in order to understand the interaction of enantioseparation, the inclusion complex formation between NSAIDs and β-CD-BIMOTs was studied using 1 H NMR, NOESY and UV/Vis. The enantioseparated NSAIDs were found to form multiple interactions with β-CD-BIMOTs-CSP.https://doi.org/10.1177/0263617416686798 |
| spellingShingle | Nurul Yani Rahim Kheng Soo Tay Sharifah Mohamad Chromatographic and spectroscopic studies on β-cyclodextrin functionalized ionic liquid as chiral stationary phase: Enantioseparation of NSAIDs Adsorption Science & Technology |
| title | Chromatographic and spectroscopic studies on β-cyclodextrin functionalized ionic liquid as chiral stationary phase: Enantioseparation of NSAIDs |
| title_full | Chromatographic and spectroscopic studies on β-cyclodextrin functionalized ionic liquid as chiral stationary phase: Enantioseparation of NSAIDs |
| title_fullStr | Chromatographic and spectroscopic studies on β-cyclodextrin functionalized ionic liquid as chiral stationary phase: Enantioseparation of NSAIDs |
| title_full_unstemmed | Chromatographic and spectroscopic studies on β-cyclodextrin functionalized ionic liquid as chiral stationary phase: Enantioseparation of NSAIDs |
| title_short | Chromatographic and spectroscopic studies on β-cyclodextrin functionalized ionic liquid as chiral stationary phase: Enantioseparation of NSAIDs |
| title_sort | chromatographic and spectroscopic studies on β cyclodextrin functionalized ionic liquid as chiral stationary phase enantioseparation of nsaids |
| url | https://doi.org/10.1177/0263617416686798 |
| work_keys_str_mv | AT nurulyanirahim chromatographicandspectroscopicstudiesonbcyclodextrinfunctionalizedionicliquidaschiralstationaryphaseenantioseparationofnsaids AT khengsootay chromatographicandspectroscopicstudiesonbcyclodextrinfunctionalizedionicliquidaschiralstationaryphaseenantioseparationofnsaids AT sharifahmohamad chromatographicandspectroscopicstudiesonbcyclodextrinfunctionalizedionicliquidaschiralstationaryphaseenantioseparationofnsaids |