Promotion of NLRP3 autophagosome degradation by PV-K nanodevice for protection against macrophage pyroptosis-mediated lung injury

Promotion of NLRP3 autophagosome degradation by PV-K nanodevice for protection against macrophage pyroptosis-mediated lung injury

Abstract Acute respiratory distress syndrome (ARDS) has emerged as a significant global health challenge, with no definitive curative treatment available. Recent evidence suggests that pyroptosis of immune cells plays a pivotal role in the pathogenesis of ARDS. Targeting and modulating immune cell p...

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Main Authors: Yan Fan, Jian Mei, Yuehao Shen, Ying Gao, Lina Zhao, Shuqi Meng, Shuai Zhou, Yu Qian, Ying Zhang, Zhiwei Wang, Yu Song, Jianfeng Liu, Shuaijie Pei, Yan Cui, Hong Yang, Shan-Yu Fung, Keliang Xie
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Nanobiotechnology
Subjects:
NLRP3
Macrophage
Nanoparticles
Autophagosome
ALI/ARDS
Online Access:https://doi.org/10.1186/s12951-025-03219-y
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https://doi.org/10.1186/s12951-025-03219-y

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