YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution

YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution

Abstract Tumor initiation represents the first step in tumorigenesis during which normal progenitor cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo, however, remains elusive. Here we employ spatiotemporally controlled oncogene activation and tumor suppressor...

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Main Authors: Farhoud Faraji, Sydney I. Ramirez, Lauren M. Clubb, Kuniaki Sato, Valeria Burghi, Thomas S. Hoang, Adam Officer, Paola Y. Anguiano Quiroz, William M. G. Galloway, Zbigniew Mikulski, Kate Medetgul-Ernar, Pauline Marangoni, Kyle B. Jones, Yuwei Cao, Alfredo A. Molinolo, Kenneth Kim, Kanako Sakaguchi, Joseph A. Califano, Quinton Smith, Alon Goren, Ophir D. Klein, Pablo Tamayo, J. Silvio Gutkind
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55660-6
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