Studies on nanoprotein vaccine alleviating symptoms of mice allergic to rFel d 1

Studies on nanoprotein vaccine alleviating symptoms of mice allergic to rFel d 1

IntroductionGlobally, cat allergens are a common cause of allergic rhinitis and asthma. Fel d 1 is the primary allergen among cat allergens and can induce a broad range of allergies through airborne transmission.MethodsIn our study, we constructed layered double hydroxide (LDH) nanoparticles loaded...

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Main Authors: Yanqi Mai, Xiaozheng Sun, Xiaoxuan Liu, Huricha Chen, Xinglan Liang, Ying Huang, Xiaojuan Wu, Shuangshuang Wei, Dayong Wang, Yechun Pei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
rFel d 1 antigen
asthma
vaccine
layered double hydroxides
T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1524929/full
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Summary:IntroductionGlobally, cat allergens are a common cause of allergic rhinitis and asthma. Fel d 1 is the primary allergen among cat allergens and can induce a broad range of allergies through airborne transmission.MethodsIn our study, we constructed layered double hydroxide (LDH) nanoparticles loaded with PADRE-rFel d 1, aiming to address allergies triggered by Fel d 1. We utilized a mouse model sensitized with purified rFel d 1 and then immunized them subcutaneously with LDH nanoparticles loaded with PADRE-rFel d 1.ResultsOur results indicated that this nanoparticle vaccine effectively restored the balance of Th1/Th2 and Th17/ Treg cells, which led to a reduction in inflammatory cell infiltration, mitigated local and systemic stress responses induced by rFel d 1, decreased airway hyperresponsiveness, and lowered serum IgE levels.DiscussionConsequently, the LDH loaded with PADRE-rFel d 1 vaccine shows promise as an effective treatment for cat allergies.
ISSN:1664-3224

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