Pyruvate–GPR31 axis induces LysoDC dendrite protrusion to M-cell pockets for effective immune responses

Pyruvate–GPR31 axis induces LysoDC dendrite protrusion to M-cell pockets for effective immune responses

Peyer’s patches (PPs) are sites of antigen entry and immunoinduction in the small intestine. In PPs, pathogens are transferred through microfold (M) cells; however, the mechanisms of antigen capture by mononuclear phagocytes beneath M cells remain unclear. Here, we demonstrate that bacterial metabol...

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Main Authors: Katsuhiro Nakanishi, Takayuki Ajiro, Kaito Yukishima, Yuki Tsukamoto, Junichi Kikuta, Shinichiro Sawa, Michio Tomura, Nozomi Kinoshita, Wataru Shimanuki, Akio Suzuki, Shun Arai, Kazuki Maeshima, Takumi Ichisawa, Tomoya Katakai, Haruko Hayasaka, Masaru Ishii, Eiji Umemoto
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Peyer’s patch
commensal metabolite
GPCR: dendritic cell
Listeria monocytogenes
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2536089
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https://www.tandfonline.com/doi/10.1080/19490976.2025.2536089

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