Pyruvate–GPR31 axis induces LysoDC dendrite protrusion to M-cell pockets for effective immune responses
Peyer’s patches (PPs) are sites of antigen entry and immunoinduction in the small intestine. In PPs, pathogens are transferred through microfold (M) cells; however, the mechanisms of antigen capture by mononuclear phagocytes beneath M cells remain unclear. Here, we demonstrate that bacterial metabol...
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| Main Authors: | Katsuhiro Nakanishi, Takayuki Ajiro, Kaito Yukishima, Yuki Tsukamoto, Junichi Kikuta, Shinichiro Sawa, Michio Tomura, Nozomi Kinoshita, Wataru Shimanuki, Akio Suzuki, Shun Arai, Kazuki Maeshima, Takumi Ichisawa, Tomoya Katakai, Haruko Hayasaka, Masaru Ishii, Eiji Umemoto |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2536089 |
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