Combination of First Derivative Spectrophotometry and H-Point Standard Addition Method for Simultaneous Determination of Guaifenesin and Theophylline in Cough Syrup
Combination of first derivative spectrophotometric and H-point standard addition method (HPSAM) has been applied for simultaneous determination of guaifenesin and theophylline. First derivative signals at the two pairs of wavelengths, 282.0-290.2 nm and 277.4-287.8 nm were monitored with the additio...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/424708 |
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| author | R. Hajian N. Shams Z. Davarpanah |
| author_facet | R. Hajian N. Shams Z. Davarpanah |
| author_sort | R. Hajian |
| collection | DOAJ |
| description | Combination of first derivative spectrophotometric and H-point standard addition method (HPSAM) has been applied for simultaneous determination of guaifenesin and theophylline. First derivative signals at the two pairs of wavelengths, 282.0-290.2 nm and 277.4-287.8 nm were monitored with the addition of standard solutions of both guaifenesin and theophylline in the ratio of 1:1. The method is able to accurately determine guaifenesin and theophylline (1:5 to 10:1) mole ratios. Accuracy and reproducibility of the determination method on the various amounts of guaifenesin and theophylline with known concentrations were evaluated in their binary mixtures. The recommended procedure was successfully applied to some cough syrups and synthetic mixtures with satisfactory results. |
| format | Article |
| id | doaj-art-e4bf340df40c4b96ae623e1894d78469 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-e4bf340df40c4b96ae623e1894d784692025-02-03T05:51:42ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018396697610.1155/2011/424708Combination of First Derivative Spectrophotometry and H-Point Standard Addition Method for Simultaneous Determination of Guaifenesin and Theophylline in Cough SyrupR. Hajian0N. Shams1Z. Davarpanah2Young Researchers Club, College of Science, Chemistry Department, Islamic Azad University Branch of Gachsaran, Gachsaran, 75818 63876, IranYoung Researchers Club, College of Science, Chemistry Department, Islamic Azad University Branch of Gachsaran, Gachsaran, 75818 63876, IranYoung Researchers Club, College of Science, Chemistry Department, Islamic Azad University Branch of Gachsaran, Gachsaran, 75818 63876, IranCombination of first derivative spectrophotometric and H-point standard addition method (HPSAM) has been applied for simultaneous determination of guaifenesin and theophylline. First derivative signals at the two pairs of wavelengths, 282.0-290.2 nm and 277.4-287.8 nm were monitored with the addition of standard solutions of both guaifenesin and theophylline in the ratio of 1:1. The method is able to accurately determine guaifenesin and theophylline (1:5 to 10:1) mole ratios. Accuracy and reproducibility of the determination method on the various amounts of guaifenesin and theophylline with known concentrations were evaluated in their binary mixtures. The recommended procedure was successfully applied to some cough syrups and synthetic mixtures with satisfactory results.http://dx.doi.org/10.1155/2011/424708 |
| spellingShingle | R. Hajian N. Shams Z. Davarpanah Combination of First Derivative Spectrophotometry and H-Point Standard Addition Method for Simultaneous Determination of Guaifenesin and Theophylline in Cough Syrup E-Journal of Chemistry |
| title | Combination of First Derivative Spectrophotometry and H-Point Standard Addition Method for Simultaneous Determination of Guaifenesin and Theophylline in Cough Syrup |
| title_full | Combination of First Derivative Spectrophotometry and H-Point Standard Addition Method for Simultaneous Determination of Guaifenesin and Theophylline in Cough Syrup |
| title_fullStr | Combination of First Derivative Spectrophotometry and H-Point Standard Addition Method for Simultaneous Determination of Guaifenesin and Theophylline in Cough Syrup |
| title_full_unstemmed | Combination of First Derivative Spectrophotometry and H-Point Standard Addition Method for Simultaneous Determination of Guaifenesin and Theophylline in Cough Syrup |
| title_short | Combination of First Derivative Spectrophotometry and H-Point Standard Addition Method for Simultaneous Determination of Guaifenesin and Theophylline in Cough Syrup |
| title_sort | combination of first derivative spectrophotometry and h point standard addition method for simultaneous determination of guaifenesin and theophylline in cough syrup |
| url | http://dx.doi.org/10.1155/2011/424708 |
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