Clinical characteristics and prognosis of dialysis patients with metastatic calcification diagnosed by 99mTc-MDP bone scintigraphy
Abstract To analyze the clinical characteristics of patients with metastatic calcification undergoing maintenance dialysis. Patients diagnosed with metastatic calcification via 99mTc-MDP bone scintigraphy between June 2019 and March 2023 at our hospital were included in this study. All patients were...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84633-4 |
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| Summary: | Abstract To analyze the clinical characteristics of patients with metastatic calcification undergoing maintenance dialysis. Patients diagnosed with metastatic calcification via 99mTc-MDP bone scintigraphy between June 2019 and March 2023 at our hospital were included in this study. All patients were followed from the time of diagnosis until death, loss to follow-up, or the study endpoint (July 2023). The primary endpoint was all-cause mortality. The cohort comprised 7 males and 3 females, with a mean age of (48.7 ± 11.1) years. The most common sites of metastatic calcification included the lungs, joints, and skin, while rarer sites involved the stomach, myocardium, and mandibular angle. Nine patients received treatment with sodium thiosulfate, with a mean duration of STS administration of 23.5 days (range: 13.25 to 56.5 days). The mean follow-up duration was 14 months (range: 10 to 20 months). One patient died, one was lost to follow-up, while 8 out of 10 patients survived, and 6 out of 10 patients were followed for more than one year. 99mTc-MDP bone scintigraphy demonstrates high sensitivity and specificity for detecting metastatic calcification. The most frequently affected sites are the lungs, joints, and skin, with less common sites being the stomach, myocardium, and mandibular angle. Eight patients (8/10) survived, and 6 patients (6/10) remained alive with over one year of follow-up. |
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| ISSN: | 2045-2322 |