Viral mediated α-synuclein overexpression results in greater transgene levels and α-synuclein overload in mice bearing kinase dead mutation of LRRK2

Viral mediated α-synuclein overexpression results in greater transgene levels and α-synuclein overload in mice bearing kinase dead mutation of LRRK2

Abstract The relationship between LRRK2 mutations and susceptibility to synuclein pathology in Parkinson’s disease (PD) is still unclear. We here investigate whether the mice carrying the D1994S kinase-dead (KD) mutation of LRRK2 show enhanced susceptibility to synucleinopathy. Twelve-month-old LRRK...

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Bibliographic Details
Main Authors: Federica Albanese, Chiara Domenicale, Daniela Mercatelli, Alberto Brugnoli, Sandra Dovero, Erwan Bezard, Michele Morari
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
AAV2/9
D1994S LRRK2
Kinase-dead
Parkinson’s disease
Α-synuclein
Viral vectors
Online Access:https://doi.org/10.1038/s41598-025-94165-0
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https://doi.org/10.1038/s41598-025-94165-0

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