Sibling similarity can reveal key insights into genetic architecture

The use of siblings to infer the factors influencing complex traits has been a cornerstone of quantitative genetics. Here, we utilise siblings for a novel application: the inference of genetic architecture, specifically that relating to individuals with extreme trait values (e.g. in the top 1%). Inf...

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Bibliographic Details
Main Authors: Tade Souaiaia, Hei Man Wu, Clive Hoggart, Paul F O'Reilly
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-01-01
Series:eLife
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Online Access:https://elifesciences.org/articles/87522
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