MET inhibition overcomes radiation resistance of glioblastoma stem‐like cells

MET inhibition overcomes radiation resistance of glioblastoma stem‐like cells

Abstract Glioblastoma (GBM) contains stem‐like cells (GSCs) known to be resistant to ionizing radiation and thus responsible for therapeutic failure and rapidly lethal tumor recurrence. It is known that GSC radioresistance relies on efficient activation of the DNA damage response, but the mechanisms...

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Main Authors: Francesca De Bacco, Antonio D'Ambrosio, Elena Casanova, Francesca Orzan, Roberta Neggia, Raffaella Albano, Federica Verginelli, Manuela Cominelli, Pietro L Poliani, Paolo Luraghi, Gigliola Reato, Serena Pellegatta, Gaetano Finocchiaro, Timothy Perera, Elisabetta Garibaldi, Pietro Gabriele, Paolo M Comoglio, Carla Boccaccio
Format: Article
Language:English
Published: Springer Nature 2016-04-01
Series:EMBO Molecular Medicine
Subjects:
glioblastoma
glioblastoma stem‐like cells
MET oncogene
radiosensitization
radiotherapy
Online Access:https://doi.org/10.15252/emmm.201505890
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https://doi.org/10.15252/emmm.201505890

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