Role of insulin-like growth factor-2 in Alzheimer’s disease induced memory impairment and underlying mechanisms
Alzheimer’s disease (AD) is the most prevalent type of dementia. Treatments for AD do not reverse the loss of brain function; rather, they decrease the rate of cognitive deterioration. Current treatments are ineffective in part because they do not address neurotrophic mechanisms, which are believed...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1520253/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841561073347461120 |
|---|---|
| author | Ruiqi Chen Xing Lu Anqi Xiao Junpeng Ma Junpeng Ma |
| author_facet | Ruiqi Chen Xing Lu Anqi Xiao Junpeng Ma Junpeng Ma |
| author_sort | Ruiqi Chen |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the most prevalent type of dementia. Treatments for AD do not reverse the loss of brain function; rather, they decrease the rate of cognitive deterioration. Current treatments are ineffective in part because they do not address neurotrophic mechanisms, which are believed to be critical for functional recovery. Given that structural losses are assumed to be the root cause of cognitive impairment in AD, strengthening neurotrophic pathways may be a useful preventative therapeutic approach. Insulin-like growth factor-2 (IGF2), which is widely expressed in the central nervous system (CNS), has emerged as a crucial mechanism of synaptic plasticity and learning and memory, and many studies have indicated that this neurotrophic peptide is a viable candidate for treating and preventing AD-induced cognitive decline. An increase in IGF2 levels improves memory in healthy animals and alleviates several symptoms associated with neurodegenerative disorders. These effects are primarily caused by the IGF2 receptor, which is widely expressed in neurons and controls protein trafficking, synthesis, and degradation. However, the use of IGF2 as a potential target for the development of novel pharmaceuticals to treat AD-induced memory impairment needs further investigation. We compiled recent studies on the role of IGF2 in AD-associated memory issues and summarized the current knowledge regarding IGF2 expression and function in the brain, specifically in AD-induced memory impairment. |
| format | Article |
| id | doaj-art-e36dc4d0742641a68a289e79ec153e4d |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-e36dc4d0742641a68a289e79ec153e4d2025-01-03T06:46:51ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-01-011810.3389/fncel.2024.15202531520253Role of insulin-like growth factor-2 in Alzheimer’s disease induced memory impairment and underlying mechanismsRuiqi Chen0Xing Lu1Anqi Xiao2Junpeng Ma3Junpeng Ma4Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Gynecological Nursing, West China Second Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Tianfu Hospital of Sichuan University, Chengdu, ChinaAlzheimer’s disease (AD) is the most prevalent type of dementia. Treatments for AD do not reverse the loss of brain function; rather, they decrease the rate of cognitive deterioration. Current treatments are ineffective in part because they do not address neurotrophic mechanisms, which are believed to be critical for functional recovery. Given that structural losses are assumed to be the root cause of cognitive impairment in AD, strengthening neurotrophic pathways may be a useful preventative therapeutic approach. Insulin-like growth factor-2 (IGF2), which is widely expressed in the central nervous system (CNS), has emerged as a crucial mechanism of synaptic plasticity and learning and memory, and many studies have indicated that this neurotrophic peptide is a viable candidate for treating and preventing AD-induced cognitive decline. An increase in IGF2 levels improves memory in healthy animals and alleviates several symptoms associated with neurodegenerative disorders. These effects are primarily caused by the IGF2 receptor, which is widely expressed in neurons and controls protein trafficking, synthesis, and degradation. However, the use of IGF2 as a potential target for the development of novel pharmaceuticals to treat AD-induced memory impairment needs further investigation. We compiled recent studies on the role of IGF2 in AD-associated memory issues and summarized the current knowledge regarding IGF2 expression and function in the brain, specifically in AD-induced memory impairment.https://www.frontiersin.org/articles/10.3389/fncel.2024.1520253/fullIGF2memoryADhippocampustreatment |
| spellingShingle | Ruiqi Chen Xing Lu Anqi Xiao Junpeng Ma Junpeng Ma Role of insulin-like growth factor-2 in Alzheimer’s disease induced memory impairment and underlying mechanisms Frontiers in Cellular Neuroscience IGF2 memory AD hippocampus treatment |
| title | Role of insulin-like growth factor-2 in Alzheimer’s disease induced memory impairment and underlying mechanisms |
| title_full | Role of insulin-like growth factor-2 in Alzheimer’s disease induced memory impairment and underlying mechanisms |
| title_fullStr | Role of insulin-like growth factor-2 in Alzheimer’s disease induced memory impairment and underlying mechanisms |
| title_full_unstemmed | Role of insulin-like growth factor-2 in Alzheimer’s disease induced memory impairment and underlying mechanisms |
| title_short | Role of insulin-like growth factor-2 in Alzheimer’s disease induced memory impairment and underlying mechanisms |
| title_sort | role of insulin like growth factor 2 in alzheimer s disease induced memory impairment and underlying mechanisms |
| topic | IGF2 memory AD hippocampus treatment |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1520253/full |
| work_keys_str_mv | AT ruiqichen roleofinsulinlikegrowthfactor2inalzheimersdiseaseinducedmemoryimpairmentandunderlyingmechanisms AT xinglu roleofinsulinlikegrowthfactor2inalzheimersdiseaseinducedmemoryimpairmentandunderlyingmechanisms AT anqixiao roleofinsulinlikegrowthfactor2inalzheimersdiseaseinducedmemoryimpairmentandunderlyingmechanisms AT junpengma roleofinsulinlikegrowthfactor2inalzheimersdiseaseinducedmemoryimpairmentandunderlyingmechanisms AT junpengma roleofinsulinlikegrowthfactor2inalzheimersdiseaseinducedmemoryimpairmentandunderlyingmechanisms |