Alcohol Exposure May Increase Prenatal Choline Needs Through Redirection of Choline into Lipid Synthesis Rather than Methyl Donation

Alcohol Exposure May Increase Prenatal Choline Needs Through Redirection of Choline into Lipid Synthesis Rather than Methyl Donation

<b>Background</b>: Prenatal alcohol exposure (PAE) can reduce fetal growth and cause neurodevelopmental disability. Prenatal choline supplements attenuate PAE-induced behavioral and growth deficits; however, the underlying mechanisms are unknown. Alcohol alters nutrient metabolism and po...

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Bibliographic Details
Main Authors: Hannah G. Petry, Nipun Saini, Susan M. Smith, Sandra M. Mooney
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Metabolites
Subjects:
fetal alcohol spectrum disorder
Kennedy pathway
metabolome
mouse
one carbon metabolism
prenatal alcohol
Online Access:https://www.mdpi.com/2218-1989/15/5/289
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