Parvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in rats
The anterior cingulate cortex is responsible for multiple cognitive functions like fear, pain management, decision-making, risk and reward assessment, and memory consolidation. However, its cell-type-specific functions are not clearly understood. To reveal the selective functional role of Parvalbumi...
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024172490 |
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| author | Muhammad Jahangir S. Mudasser Shah Jian-Song Zhou Bing Lang Xiao-Ping Wang |
| author_facet | Muhammad Jahangir S. Mudasser Shah Jian-Song Zhou Bing Lang Xiao-Ping Wang |
| author_sort | Muhammad Jahangir |
| collection | DOAJ |
| description | The anterior cingulate cortex is responsible for multiple cognitive functions like fear, pain management, decision-making, risk and reward assessment, and memory consolidation. However, its cell-type-specific functions are not clearly understood. To reveal the selective functional role of Parvalbumin-expressing GABAergic interneurons in the ACC, we knocked down (KD) the PV gene in-vivo in rats. Behavioral tests showed significantly improved spatial memory (p = 0.01) in ACC-PV-KD rats compared to control and sham groups, whereas novel object recognition memory was reduced significantly (p = 0.001). The PV knockdown group also showed a longer freezing duration (p = 0.001) and considerably fewer freezing responses (p = 0.005) in the fear conditioning chamber. Additionally, the PV knockdown rats spent significantly (p = 0.006) more time in the periphery and less time in the center of the open field box, indicating anxiety-like behavior. In conclusion, Parvalbumin expressing interneurons in ACC are functionally diverse and critical for regulating fear response, recognition memory and spatial memory. Completely elucidating the underlying mechanism and circuitry will open up therapeutic choices for associated disorders. |
| format | Article |
| id | doaj-art-e32cd2b7f37b468bb93622cb76b5b33d |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-e32cd2b7f37b468bb93622cb76b5b33d2025-01-17T04:50:33ZengElsevierHeliyon2405-84402025-01-01111e41218Parvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in ratsMuhammad Jahangir0S. Mudasser Shah1Jian-Song Zhou2Bing Lang3Xiao-Ping Wang4Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaInstitute of Developmental Psychology, School of Psychology, Beijing Normal University, Beijing, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China; Corresponding author.Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China; Corresponding author.The anterior cingulate cortex is responsible for multiple cognitive functions like fear, pain management, decision-making, risk and reward assessment, and memory consolidation. However, its cell-type-specific functions are not clearly understood. To reveal the selective functional role of Parvalbumin-expressing GABAergic interneurons in the ACC, we knocked down (KD) the PV gene in-vivo in rats. Behavioral tests showed significantly improved spatial memory (p = 0.01) in ACC-PV-KD rats compared to control and sham groups, whereas novel object recognition memory was reduced significantly (p = 0.001). The PV knockdown group also showed a longer freezing duration (p = 0.001) and considerably fewer freezing responses (p = 0.005) in the fear conditioning chamber. Additionally, the PV knockdown rats spent significantly (p = 0.006) more time in the periphery and less time in the center of the open field box, indicating anxiety-like behavior. In conclusion, Parvalbumin expressing interneurons in ACC are functionally diverse and critical for regulating fear response, recognition memory and spatial memory. Completely elucidating the underlying mechanism and circuitry will open up therapeutic choices for associated disorders.http://www.sciencedirect.com/science/article/pii/S2405844024172490Anterior cingulate cortexParvalbumin interneuronsMemoryFear |
| spellingShingle | Muhammad Jahangir S. Mudasser Shah Jian-Song Zhou Bing Lang Xiao-Ping Wang Parvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in rats Heliyon Anterior cingulate cortex Parvalbumin interneurons Memory Fear |
| title | Parvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in rats |
| title_full | Parvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in rats |
| title_fullStr | Parvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in rats |
| title_full_unstemmed | Parvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in rats |
| title_short | Parvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in rats |
| title_sort | parvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in rats |
| topic | Anterior cingulate cortex Parvalbumin interneurons Memory Fear |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024172490 |
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