Antiviral immunity within neural stem cells distinguishes Enterovirus-D68 strain differences in forebrain organoids

Antiviral immunity within neural stem cells distinguishes Enterovirus-D68 strain differences in forebrain organoids

Abstract Neural stem cells have intact innate immune responses that protect them from virus infection and cell death. Yet, viruses can antagonize such responses to establish neuropathogenesis. Using a forebrain organoid model system at two developmental time points, we identified that neural stem ce...

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Bibliographic Details
Main Authors: Christine Vazquez, Seble G. Negatu, Carl D. Bannerman, Sowmya Sriram, Guo-Li Ming, Kellie A. Jurado
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Neuroinflammation
Subjects:
EV-D68
Innate immunity
Central nervous system
Forebrain organoids
Neurons
Neural stem cell
Online Access:https://doi.org/10.1186/s12974-024-03275-5
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https://doi.org/10.1186/s12974-024-03275-5

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