Performance of lung cancer screening with low‐dose CT in Gejiu, Yunnan: A population‐based, screening cohort study
Background The performance of lung cancer screening with low‐dose computed tomography (CT) (LDCT) in China is uncertain. This study aimed to evaluate the performance of LDCT lung cancer screening in the Chinese setting. Methods In 2014, a screening cohort of lung cancer with LDCT was established in...
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| Format: | Article |
| Language: | English |
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Wiley
2020-05-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.13379 |
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| author | Meng‐Na Wei Zheng Su Jian‐Ning Wang Maria J. Gonzalez Mendez Xiao‐Yun Yu Hao Liang Qing‐Hua Zhou Ya‐Guang Fan You‐Lin Qiao |
| author_facet | Meng‐Na Wei Zheng Su Jian‐Ning Wang Maria J. Gonzalez Mendez Xiao‐Yun Yu Hao Liang Qing‐Hua Zhou Ya‐Guang Fan You‐Lin Qiao |
| author_sort | Meng‐Na Wei |
| collection | DOAJ |
| description | Background The performance of lung cancer screening with low‐dose computed tomography (CT) (LDCT) in China is uncertain. This study aimed to evaluate the performance of LDCT lung cancer screening in the Chinese setting. Methods In 2014, a screening cohort of lung cancer with LDCT was established in Gejiu, Yunnan Province, a screening center of the Lung Cancer Screening Program in Rural China (LungSPRC). Participants received a baseline screening and four rounds of annual screening with LDCT in two local hospitals until June 2019. We analyzed the rates of participation, detection, early detection, and the clinical characteristics of lung cancer. Results A total of 2006 participants had complete baseline screening results with a compliance rate of 98.4%. Of these, 1411 were high‐risk and 558 were nonhigh‐risk participants. During this period, 40 lung cancer cases were confirmed, of these, 35 were screen‐detected, four were post‐screening and one was an interval case. The positive rate of baseline and annual screening was 9.7% and 9.0%, while the lung cancer detection rate was 0.4% and 0.6%, respectively. The proportion of early lung cancer increased from 37.5% in T0 to 75.0% in T4. Adenocarcinoma was the most common histological subtype. Lung cancer incidence according to the criteria of LungSPRC and National Lung Cancer Screening Trial (NLST) was 513.31 and 877.41 per 100 000 person‐years, respectively. Conclusions The program of lung cancer screening with LDCT showed a successful performance in Gejiu, Yunnan. However, further studies are warranted to refine a high‐risk population who will benefit most from LDCT screening and reduce the high false positive results. Key points This study reports the results of lung cancer screening with LDCT in Gejiu, Yunnan, a high‐risk area of lung cancer, and it demonstrates that lung cancer screening with LDCT is effective in detecting early‐stage lung cancer. Our program provides an opportunity to explore the performance of LDCT lung cancer screening in the Chinese context. |
| format | Article |
| id | doaj-art-e2fe6099eea848ed8da77f5a2bc34572 |
| institution | Kabale University |
| issn | 1759-7706 1759-7714 |
| language | English |
| publishDate | 2020-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj-art-e2fe6099eea848ed8da77f5a2bc345722025-08-26T10:24:34ZengWileyThoracic Cancer1759-77061759-77142020-05-011151224123210.1111/1759-7714.13379Performance of lung cancer screening with low‐dose CT in Gejiu, Yunnan: A population‐based, screening cohort studyMeng‐Na Wei0Zheng Su1Jian‐Ning Wang2Maria J. Gonzalez Mendez3Xiao‐Yun Yu4Hao Liang5Qing‐Hua Zhou6Ya‐Guang Fan7You‐Lin Qiao8Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaOffice of Gejiu Municipal Leading Group for Cancer Prevention and Control Gejiu ChinaSchool of Public Health Dalian Medical University Dalian ChinaOffice of Gejiu Municipal Leading Group for Cancer Prevention and Control Gejiu ChinaLung Cancer Center/Lung Cancer Institute West China Hospital, Sichuan University Chengdu ChinaLung Cancer Center/Lung Cancer Institute West China Hospital, Sichuan University Chengdu ChinaTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaBackground The performance of lung cancer screening with low‐dose computed tomography (CT) (LDCT) in China is uncertain. This study aimed to evaluate the performance of LDCT lung cancer screening in the Chinese setting. Methods In 2014, a screening cohort of lung cancer with LDCT was established in Gejiu, Yunnan Province, a screening center of the Lung Cancer Screening Program in Rural China (LungSPRC). Participants received a baseline screening and four rounds of annual screening with LDCT in two local hospitals until June 2019. We analyzed the rates of participation, detection, early detection, and the clinical characteristics of lung cancer. Results A total of 2006 participants had complete baseline screening results with a compliance rate of 98.4%. Of these, 1411 were high‐risk and 558 were nonhigh‐risk participants. During this period, 40 lung cancer cases were confirmed, of these, 35 were screen‐detected, four were post‐screening and one was an interval case. The positive rate of baseline and annual screening was 9.7% and 9.0%, while the lung cancer detection rate was 0.4% and 0.6%, respectively. The proportion of early lung cancer increased from 37.5% in T0 to 75.0% in T4. Adenocarcinoma was the most common histological subtype. Lung cancer incidence according to the criteria of LungSPRC and National Lung Cancer Screening Trial (NLST) was 513.31 and 877.41 per 100 000 person‐years, respectively. Conclusions The program of lung cancer screening with LDCT showed a successful performance in Gejiu, Yunnan. However, further studies are warranted to refine a high‐risk population who will benefit most from LDCT screening and reduce the high false positive results. Key points This study reports the results of lung cancer screening with LDCT in Gejiu, Yunnan, a high‐risk area of lung cancer, and it demonstrates that lung cancer screening with LDCT is effective in detecting early‐stage lung cancer. Our program provides an opportunity to explore the performance of LDCT lung cancer screening in the Chinese context.https://doi.org/10.1111/1759-7714.13379Cohort studyLDCTlung cancerscreening |
| spellingShingle | Meng‐Na Wei Zheng Su Jian‐Ning Wang Maria J. Gonzalez Mendez Xiao‐Yun Yu Hao Liang Qing‐Hua Zhou Ya‐Guang Fan You‐Lin Qiao Performance of lung cancer screening with low‐dose CT in Gejiu, Yunnan: A population‐based, screening cohort study Thoracic Cancer Cohort study LDCT lung cancer screening |
| title | Performance of lung cancer screening with low‐dose CT in Gejiu, Yunnan: A population‐based, screening cohort study |
| title_full | Performance of lung cancer screening with low‐dose CT in Gejiu, Yunnan: A population‐based, screening cohort study |
| title_fullStr | Performance of lung cancer screening with low‐dose CT in Gejiu, Yunnan: A population‐based, screening cohort study |
| title_full_unstemmed | Performance of lung cancer screening with low‐dose CT in Gejiu, Yunnan: A population‐based, screening cohort study |
| title_short | Performance of lung cancer screening with low‐dose CT in Gejiu, Yunnan: A population‐based, screening cohort study |
| title_sort | performance of lung cancer screening with low dose ct in gejiu yunnan a population based screening cohort study |
| topic | Cohort study LDCT lung cancer screening |
| url | https://doi.org/10.1111/1759-7714.13379 |
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