LCT-3d Induces Oxidative Stress-Mediated Apoptosis by Upregulating Death Receptor 5 in Gastric Cancer Cells

LCT-3d Induces Oxidative Stress-Mediated Apoptosis by Upregulating Death Receptor 5 in Gastric Cancer Cells

Gastric cancer is a global health problem. In this study, we investigate the role of a novel Indole derivative, named LCT-3d, in inhibiting the growth of gastric cancer cells by MTT assay. The Western blotting results showed that LCT-3d modulated the mitochondrial-related proteins and Cleaved-Caspas...

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Bibliographic Details
Main Authors: Menglin Wang, Xinxin Wu, Lu Yu, Zi-yun Hu, Xiaobo Li, Xia Meng, Chun-tao Lv, Gi-Young Kim, Yung Hyun Choi, Zhenya Wang, Hai-Wei Xu, Cheng-Yun Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
LCT-3d
DR5
reactive oxygen species
Nrf2
apoptosis
gastric cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.658608/full
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https://www.frontiersin.org/articles/10.3389/fonc.2021.658608/full

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