Robust BRCA1‐like classification of copy number profiles of samples repeated across different datasets and platforms

Robust BRCA1‐like classification of copy number profiles of samples repeated across different datasets and platforms

Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be ‘BRCA1‐like’ or ‘non‐BRCA1‐like’, which refers to resembling a BRCA1‐mutated tumor or resembling a tumor without a BRCA1 mutation, respectively. Approxim...

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Main Authors: Philip C. Schouten, Anita Grigoriadis, Thomas Kuilman, Hasan Mirza, Johnathan A. Watkins, Saskia A. Cooke, Ewald van Dyk, Tesa M. Severson, Oscar M. Rueda, Marlous Hoogstraat, Caroline V.M. Verhagen, Rachael Natrajan, Suet-Feung Chin, Esther H. Lips, Janneke Kruizinga, Arno Velds, Marja Nieuwland, Ron M. Kerkhoven, Oscar Krijgsman, Conchita Vens, Daniel Peeper, Petra M. Nederlof, Carlos Caldas, Andrew N. Tutt, Lodewyk F. Wessels, Sabine C. Linn
Format: Article
Language:English
Published: Wiley 2015-08-01
Series:Molecular Oncology
Subjects:
BRCA1
Breast cancer
Classification
Copy number aberration profiles
Online Access:https://doi.org/10.1016/j.molonc.2015.03.002
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https://doi.org/10.1016/j.molonc.2015.03.002

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